Abstract:
Prostate Cancer (PCa) has been the most common cancer in the world for several decades, and by 2008, there were an estimated 899,000 new cases representing 13.7% of the total. Nearly three-quarters i.e. 71.6% cases occur in developed countries whereas 28.4% cases occur in less developed countries. Worldwide, prostate cancer ranks third in cancer incidence and sixth in cancer mortality among men. Incidence rates of prostate cancer varies more than twenty-fold worldwide. The CYP3A4 and CYP3A5 genetic polymorphisms on susceptibility to prostate cancer have received particular interest since these enzymes play a central role in detoxification of major classes of carcinogens, free radicals, xenobiotics and cytotoxic drugs. In the current study we investigated the role of CYP3A4 and CYP3A5 polymorphisms as a genetic modifier of risk for individuals with prostate cancer as susceptible genotypes in Bangladeshi population.
