Effect of GSTP1 and ABCC4 gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-5-fluorouracil based chemotherapy in Bangladeshi breast cancer patients

Abstract

Chemotherapy is one of the most widely used treatments of breast cancer with the limitation of significant inter-individual heterogenecity in response as well as in toxicity. The most important cytotoxic drug namely cyclophosphamide (CPA) used in breast cancer along with epirubicin and 5-fluorouracil, is transported by ABCC transporters and detoxified by glutathione S-transferases (GSTs). It has been established that the activities of these enzymes and transporters vary in different population due to the presence of polymorphisms in their genetic sequence but no such type of study has been conducted on Bangladeshi breast cancer patients. The goal of this study was to evaluate the effects of genetic polymorphism of GSTP1 (rs1695) and ABCC4 (rs9561778) genes on the response and toxicities produced by chemotherapy used in the treatment of breast cancer.