Abstract:
A number of pyridopyrimidines 64-66 were synthesized by the reaction of arylideneacetophenones 58-59 with barbituric acid 1 or 2-thiobarbituric acid 2 in presence of ammonium acetate (NH4OAc) in ethanol (EtOH) and acetic acid (CH3COOH). Spiro compounds 67-73 were also synthesized by the reaction of arylideneacetophenones 58-63 with barbituric acid 1 or 2-thiobarbituric acid 2 in presence of 4-methyl benzaldehyde/4-methoxy benzaldehyde, ammonium acetate (NH4OAc) in ethanol (EtOH) and acetic acid (CH3COOH). The structure of the compounds have been determined with the help of their chemical and spectroscopic analysis. The spectroscopic methods used were- UV, IR, 1H NMR and 13C NMR. The analysis of biological activity were also performed for some compounds.
For this purpose, at first substituted arylideneacetophenones 58-63 were prepared by carrying out reactions in sodium hydroxide between substituted benzaldehydes and acetophenones. The aldehydes were used 4-methylbenzaldehyde, 4-methoxybenzaldehyde, 4-chlorobenzaldehyde, 4-nitrobenzaldehyde. The acetophenones are 4-bromoacetophenone, 4-methylacetophenone, 4-nitroacetophenone.
